It is widely known that cholesterol is essential for maintaining membrane fluidity, signal transduction, and participating in lipid raft formation to regulate the co-localization of neurotransmitters and receptors involved in neuronal synaptic function (Lee et al., 2014), while AD-related pathologies including tau and Aβ abnormalities have both direct or indirect connection with cholesterol (van der Kant et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.