A significant increase in pAkt, p-p38, p-ERK1/2 expression was detected in the HPC-ASCCM group and the HPC-ASCCM group with removal of VEGF-A or SDF-1a alone compared with that in the NPC-ASCCM group and the HPC-ASCCM group with removal of VEGF-A and SDF-1a. Here, CXCL12 is linked to nasopharyngeal carcinoma.