Further detection proved the significant upregulation of α-SMA (Figure 3D), collagen I (Figure 3E), and collagen III (Figure 3F) in the ApoE–/–; BRG1fl/fl; CDH5-cre mice, suggesting that endothelial cell deletion of BRG1 could ameliorate Ang II induced AAA progression in mice. This evidence concerns the gene ACTA1 and triple-A syndrome.