Of interest, 4 weeks after the Ang-II infusion, the gross anatomical evaluation revealed that the abdominal aortas in WT mice became overtly enlarged, indicative of AAA development (Figure 3A); by comparison, mice with endothelial conditional Brg1 knockout (CKO) exhibited an appreciable reduction in aortic enlargement. Here, SMARCA4 is linked to triple-A syndrome.