Syndecan 2 (Sdc-2) expression is increased in a range of cancers including lung adenocarcinoma and colon cancer, where it promotes expression of matrix metalo-proteinase 9 and 7 (MMP9 and MMP7) respectively (Jang et al., 2016; Tsoyi et al., 2019). The gene discussed is SDC2; the disease is colonic neoplasm.