VIM and cancer: High expression of PLEC is associated with poor prognosis in breast and colorectal cancer and was reported to drive cancer metastasis, by stabilizing invadopodia via anchoring to vimentin intermediate filament scaffolds, a necessary process in cancer cell invasion and extravasation (Chao et al., 1996; Lu et al., 2008; Sutoh Yoneyama et al., 2014).