H3K27me3 is required for EZH2-mediated repression of various genes essential for tumorigenesis and tumor development, while the expression of H3K27me3 and EZH2 could serve as biomarkers in the prediction of ESCC patients’ survival and ESCC metastasis (Liu et al., 2016). Here, EZH2 is linked to esophageal squamous cell carcinoma.