EZH2 and cancer: Likewise, a similar interplay has been reported in ESCC whereby lncRNA metastasis-associated lung adenocarcinoma transcript 1 can promote malignant development by targeting β-catenin via EZH2 and lncRNA cancer susceptibility candidate 9 to enhance ESCC growth by targeting programmed cell death protein 4 via EZH2 (di Pietro et al., 2012; Wu et al., 2017).