In Glioblastoma, the glioblastoma stem-like cells (GSCs) phenotype, the worst prognostic marker of Glioblastoma, was reported to persist due to hypoxic microenvironment-dependent release of extracellular adenosine, which in turn, promote cell migration, invasion and tumor recurrence through the activation of the A3 Adenosine Receptor (A3AR; Torres et al., 2019). The gene discussed is ADORA3; the disease is neoplasm.