GPC1 and Familial prostate cancer: Authors also observed that GPC-1 inhibition in an aggressive prostate cancer cell line, the DU-145 cells, increased cancer cell proliferation and migration, suggesting that GPC-1 accounts among the factors that drive cancer cell line-dependent responses to stromal cells Reduced cell growth observed in GPC-1 knockdown PC-3 cells was rescued by culturing the cells with MSCs and CAFs.