AKT1 and urinary bladder cancer: On the same hand, in co-cultures with stem cell-like (CD133+) cells from urinary bladder cancer cell lines, adipose-derived MSCs produced soluble mediators that: (i) increased the phosphorylation of molecules involved in cancer progression and drug resistance, such as p70 S6K, ERK1/2, and AKT1/2/3 in CD133+ cells (5,637 cell line); but instead, (ii) decreased the phosphorylation of those involved in PI3K/Akt and MAPK signaling molecules in CD133+ cells (HB-CLS-1 cell line; Maj et al., 2019).