Toward this, neutropenia was induced in mice as described above, and mice were treated with sham, a full dose of standard PEGylated G-CSF conjugated with 20 kDa PEG (1 mg/kg mice body weight) and half-dose (0.5 mg/kg mice body weight) of the Cys2-40 kDa PEG conjugate. Here, CSF3 is linked to neutropenia.