The down-regulation of HIF-1α by the Pt/BP decreased the tumor apoptotic resistance, which ultimately enhanced the therapeutic effect in the in vivo antitumor experiment, in which the growth of the tumor was completely regressed by the treatment of Pt/BP, while the treatment of BP NSs alone only led to a decline in about 47% of average tumor size. The gene discussed is HIF1A; the disease is neoplasm.