This was demonstrated by several observations—1) decreased bacterial killing by mouse leucocytes, when infected with bacteria treated with GYY4137 (0.3 and 1 mM), 2) bacterial clearance from leucocytes or RAW264.7 cells was significantly increased after inhibiting 3-MST in E. coli or CBS/CSE in S. aureus using either an inhibitor or a gene deletion mutant, and 3) Mice infected with H2S-deficient bacteria had a lower burden in the spleen and decreased plasma levels of IL-6 compared to infection with WT bacteria (Toliver-Kinsky et al., 2019). Here, CBS is linked to infection.