CBS and tuberculosis: The course of TB disease was altered in both H2S-deficient mouse models, based on the following observations: i) Mtb-infected Cse−/− and Cbs+/− mice survived significantly longer than WT mice, ii) the Mtb organ burden in the lungs, spleens and livers of Cse−/− and Cbs+/− mice was significantly lower than in WT controls, iii) histopathological analysis of the lungs revealed that Cse−/− and Cbs+/− mice had less consolidated tissue than WT mice over time, and that these mice also had fewer and smaller granulomatous lesions than corresponding WT mice.