The course of TB disease was altered in both H2S-deficient mouse models, based on the following observations: i) Mtb-infected Cse−/− and Cbs+/− mice survived significantly longer than WT mice, ii) the Mtb organ burden in the lungs, spleens and livers of Cse−/− and Cbs+/− mice was significantly lower than in WT controls, iii) histopathological analysis of the lungs revealed that Cse−/− and Cbs+/− mice had less consolidated tissue than WT mice over time, and that these mice also had fewer and smaller granulomatous lesions than corresponding WT mice. Here, CTH is linked to tuberculosis.