CBS and pancreatic ductal adenocarcinoma: In addition, AOAA treatment decreased the growth of pancreatic ductal adenocarcinoma cells (Son et al., 2013), ovarian cancer cell lines in vitro (Bhattacharyya et al., 2013), and MDA-MB-231 breast tumors in nude mice (Thornburg et al., 2008), emphasizing both the role of CBS-derived H2S in cancer pathophysiology and the therapeutic potential of inhibiting CBS enzymatic activity.