The SMOX protein played an important role in the alteration of polyamine metabolism, which catalyzed the oxidation of spermine to spermidine and produced hydrogen peroxide and aldehydes to result in apoptosis, DNA damage, and consequently the development of CRC (Goodwin et al., 2011; Snezhkina et al., 2016). The gene discussed is SMOX; the disease is colorectal carcinoma.