Fusobacterium sequences were enriched in carcinomas (Kostic et al., 2012), which could bind to host epithelial Cadherin 1 through the adhesion of FadA and invade epithelial cells from through the E-cadherin/β-catenin signaling to induce inflammation and tumor cell growth in transformed cells (Rubinstein et al., 2013; Wong and Yu, 2019; Guo P. et al., 2020). This evidence concerns the gene CDH1 and neoplasm.