To discover whether some other microbial mechanisms related to pancreatic cancer exist, besides changes in immune status (Pushalkar et al., 2018), Berk Aykut et al. observed that activation of the mannose-binding lectin–C3 cascade through the C3 complement pathway might cause inflammation induced by the oncogenic Kras, leading to fungal dysbiosis and promoting tumor progression. This evidence concerns the gene KRAS and neoplasm.