Modify the tumor-immune microenvironment through the E-cadherin/β-catenin signaling pathway to cause cancer (Audirac-Chalifour et al., 2016); induce Th2 immunity through the RORγτ+Treg cells, IL-10, and Th17 cells in the cervical epithelium (Punt et al., 2015). Here, CDH1 is linked to cancer.