Genetic modifications in astrocytes or in NSC-derived astrocytes leading to combined inactivation of several tumor suppressor genes or in driver oncogenes (EGFR) are also capable of initiating gliomagenesis in mice (60–62) (Figure 3), although other authors have reported that oncogenic mutations in mature astrocytes do not contribute to the formation of gliomas (58, 59). Here, EGFR is linked to central nervous system cancer.