Non-small cell lung cancer cells have shown DNA damage after treatment with resveratrol, which was potentiated by the pemetrexed antifolate that destabilizes ERCC1 protein, an essential nuclease in the BER pathway and, to a lesser extent, in double-stranded DNA breaks and in crosslink repair, by inhibiting p38 MAPK activity (21). The gene discussed is ERCC1; the disease is non-small cell lung carcinoma.