In hepatocellular carcinoma, sex differences are also found in several signaling pathways that are targets for anti-cancer therapies: PPAR is enriched for genes overexpressed in females, while PI3K, PI3K/AKT, EGFR, IL-2 are enriched for genes overexpressed in males (118). The gene discussed is EGFR; the disease is hepatocellular carcinoma.