The oncogenic function of numerous miRNAs has been proved in RCC cells These oncomiRs have been shown to enhance cell proliferation and invasive features of RCC cells whilst decreasing apoptosis Notably some tumor suppressor genes such PTEN APC and MEG3 have been identified as targets of oncomiRs such as miR-301a miR-193a-3p miR-22 miR-671-5p, and miR-7, indicating a possible mechanism for their participation in the pathogenesis of RCC. This evidence concerns the gene PTEN and renal cell adenocarcinoma.