The miR-181 cluster (miR-181a-3p, -5p and b-3p) showed a varied expression in their AML patients; in particular, it was high in the RUNX1/RUNX1T1-positive AML subtype, whereas only miR-181a-5p showed a steep increase in acute promyelocytic leukemia, where miR-181a-3p was usually downregulated. Here, RUNX1T1 is linked to acute myeloid leukemia.