ASPS is characterized by the recurrent unbalanced translocation der(17)t(X;17)(p11;q25) and its 2 mutually exclusive variants of inherent chimeric protein fusion (ASPSCR1-TFE3), that induce an immunosuppressive micro-environment, an overexpression of MET and angiogenesis via HIF1α overexpression (14). Here, HIF1A is linked to alveolar soft part sarcoma.