Additionally, except for conditions with pathological characteristics of microvascular proliferation or necrosis, astrocytomas with epidermal growth factor receptor (EGFR) amplification, combined whole chromosome 7 gain and whole chromosome 10 loss (+7/−10), or telomerase reverse transcriptase (TERT) promoter mutation should be diagnosed as GBM (3). This evidence concerns the gene EGFR and astrocytoma (excluding glioblastoma).