Functional NTRK fusions lead to an activation of Trk proteins, which contributed to the development of glioma (34).Preclinical research indicates that neural stem cells(NSCs) can progress into high-grade glioma when the BCAN-NTRK1 fusion protein is expressed artificially by CRISPR-Cas9 genome editing tools (14). The gene discussed is NTRK1; the disease is central nervous system cancer.