Also, another team transduced BCAN-NTRK1 gene fusions into NSCs through CRISPR-Cas9 system and replication-competent avian leukosis virus splice acceptor-tumor virus (ARCAS-TVA) system, and intracranial injection of those NSCs into mice leads to a development of high grade glioma (35). This evidence concerns the gene BCAN and central nervous system cancer.