These genes can be roughly ranged into four categories, including iron metabolism (CISD1, PRNP, HSPB1, PCBP1, STEAP3, TF, and CP), lipid metabolism and (anti)oxidant metabolism (ACACA, ACSL1, ACSL6, AKR1C3, LOX, MAP3K5, HMOX1, ANO6, and RB1), energy metabolism (G6PD, PGD, CYBB, and GLS2), and cancer metabolism (BAP1, AURKA, CDKN1A, G3BP1, and TP53) (12). This evidence concerns the gene MAP3K5 and cancer.