These genes can be roughly ranged into four categories, including iron metabolism (CISD1, PRNP, HSPB1, PCBP1, STEAP3, TF, and CP), lipid metabolism and (anti)oxidant metabolism (ACACA, ACSL1, ACSL6, AKR1C3, LOX, MAP3K5, HMOX1, ANO6, and RB1), energy metabolism (G6PD, PGD, CYBB, and GLS2), and cancer metabolism (BAP1, AURKA, CDKN1A, G3BP1, and TP53) (12). Here, CISD1 is linked to cancer.