Consistent with this finding, we also observed that cluster 2 has a poorer prognosis in Oligodendroglioma with IDH-mutant and 1p/19q co-deletion, Astrocytoma with IDH-mutant, Astrocytoma with IDH wild type, GBM with IDH-mutant, and GBM with IDH wild type based on the integrated diagnostic guideline of WHO grade 2016 (Supplementary Figure 3). Here, IDH2 is linked to astrocytoma (excluding glioblastoma).