CD4 and neoplasm: Similarly, our study also proved that acute injury-reactivated hepatocellular senescence activated immunosurveillance and promoted the activation and recruitment of NK cells and macrophages by activating CD4+ Th1 cells, thus eliminating senescent precancerous hepatocytes and further inhibiting hepatocarcinogenesis in Fah−/− mice under chronic liver injury (15), suggesting that tumor suppression to some extent is resulting from intensive induction of senescence, and subsequent immune-mediated clearance of senescent cells.