The authors have already introduced and applied fumarylacetoacetate hydrolase (Fah) knockout (Fah−/−) mice (55, 56) as an ideal animal model of inducible liver injury and even HCC (10, 15) since HCC as a result of chronic liver injury in Fah−/− mice is highly overlapped with the genetic characteristics of human HCC (57). This evidence concerns the gene FAH and hepatocellular carcinoma.