In addition, Brouwer NJ and colleagues analyzed the correlation between several angiogenesis-related cytokines and the development of tumor vessels of primary UM, founding that a high MVD is associated with an increased expression of angiopoietin 2, Von Willebrand Factor, and a decreased expression of vascular endothelial growth factor B (VEGF-B) (79). This evidence concerns the gene ANGPT2 and neoplasm.