As well, tumor infiltrating lymphocytes and/or histiocytes (49) and cytogenetic factors including monosomy 3, chromosome 8q-gain or 8p-loss, chromosome 1p-loss, chromosome 6q-loss, and high expression of insulin-like growth factor-1 receptor (IGF-1R) (50), also contribute to the definition of the class risk of each case of UM. This evidence concerns the gene IGF1R and neoplasm.