Systemically, neutralization of IL-6 and G-CSF led to a decrease in the frequency of CD11b+Ly6C+Ly6G+ myeloid cells in the spleen (Supplementary Figures 4A, B) and also reverted the tumor triggered inhibition of NFκB in antigen-presenting cells and T lymphocytes (Supplementary Figure 4C). Here, ITGAM is linked to neoplasm.