IL6 and neoplasm: Because antibody treatment can promote off-target effects and face distribution resistance inside of the tumor microenvironment to block cytokine signaling, we decided to inject TC-1 tumor cells an IL-6 deficient mice, where was observed a significant reduction in the TC-1 tumor growth compared to wild type mice growth curve (Figure 4D), confirming IL-6 role as a pro-tumoral signal.