Human hepatoma contains a high proportion of Tim-3 expressed hepatocytes, and that the overexpression of hepatocyte-specific Tim3 promotes tumor cell growth, whereas Tim3 inhibition on malignant hepatocytes by anti-Tim3 antibodies and in Tim-3 knockout mice through activating NF-κB phosphorylation by hepatocyte-Tim3 receptor mechanistically (20). This evidence concerns the gene HAVCR2 and hepatocellular carcinoma.