As a negative regulatory molecule, It has been confirmed that Tim3 can be expressed on a variety of immune cells, such as CD4+T cells (Th1, Th17), CD8+T cells, Treg cells, DCs, monocytes, mast cells, macrophages, NK cells, and plays an important role in tumor immunity in tumor microenvironment. Here, HAVCR2 is linked to neoplasm.