HAVCR2 and Miyoshi myopathy: Combining the two groups can increase the patients number we can analyse in our experiments,which will help us to explore Tim-3 in MM.As we separately analyzed the expression of tim-3 in the newly diagnosed and recurrence MM patients, we found significant difference in the expression of tim-3 in the newly diagnosed and recurrence MM patients group between stage I and III, stage II and III according to ISS stage (Supplementary Figures 1B, C).There is an obvious trend between stage I and II in both groups, which may due to the small number of specimens.