Overexpression increases angiogenesis and promotes fibroblast transformation into cancer-associated fibroblasts (CAFs) in lung cancer (213).Overexpression correlates with higher microvessel density in HCC (214), malignant peripheral nerve sheath tumor (MPNST) (215), and in oral squamous cell carcinoma (OSCC). In OSCC, its expression positively correlates with Leptin-receptor and HIF1- α expression (216).On the contrary, its overexpression down-regulates E2F3, and so inhibit tumor initiation in ovarian cancer cells (217). The gene discussed is LEPR; the disease is cancer.