For example, miR-215-5p, which is nuclear-localized, is up-regulated in high-grade gliomas and promotes tumor cell proliferation, clone formation, migration, and suppresses apoptosis by directly binding to both the promoter and 3’UTR of PCDH9 gene (a member of the protocadherin family and cadherin superfamily). The gene discussed is PCDH9; the disease is glioma.