In several tumors, such as pleuropulmonary blastoma, cystic nephroma, ovarian cancer, Wilms tumor, pituitary blastoma, and rhabdomyosarcoma, the pathogenesis is supported by reduced Dicer expression and/or impaired function that in turn induce an aberrant miRNA expression (70–73). The gene discussed is DICER1; the disease is ovarian carcinoma.