And GPR115 expression level, gender, differentiation, TNM stage, tumor size, and lymph node metastasis were significantly correlated with 5-year survival of NSCLC patients in univariate analysis (hazard ratio [HR]=1.967, 0.655, 1.458, 1.642, 1.429, and 1.580, respectively, all P < 0.05). This evidence concerns the gene ADGRF4 and metastatic malignant neoplasm in the lymph nodes.