Then the subgroup analysis of the relationship between tumor GPR115 expression and clinicopathological features in the 156 LUAD and 98 LUSC cases identified several significant correlations; namely, between GRP115 expression in LUAD samples and differentiation, tumor size, lymph node infiltration and TNM staging (χ2 = 7.241, 9.299, 7.642 and 9.702, respectively; all P < 0.05) and between GPR115 expression in LUSC samples and differentiation (χ2 = 9.240, P = 0.010, Table 3). The gene discussed is ADGRF4; the disease is neoplasm.