CD4 and neoplasm: Flow cytometry analysis of co-cultured cells upon treatment revealed dose-dependent upregulation of PD-L1 on tumor cells (Figure 4B) and dose-dependent upregulation of PD-1 (Figures 4C, D and Supplementary Figures 7A, B) and PD-L1 (Figures 4E, F and Supplementary Figures 7C, D) on CD4+ and CD8+ T-cells compared with cells incubated with untargeted TCB control.