In line with this, CEA-TCB treatment also increased the frequency of intra-tumor CXCR3+ CD8+ and CD4+ T-cells, corroborating the relevance of the CXCL10-CXCR3 axis in mediating the attraction of T-cells leading to increase of intra-tumor T-cell infiltration upon TCB treatment (25) (and unpublished data). Here, CD4 is linked to neoplasm.