CD4 and neoplasm: The activity of CEA-TCB was additionally assessed in a CEA-expressing pancreatic tumor models (HPAF-II) in humanized NSG mice resulting in 72% of tumor growth inhibition, and confirmed the previous observations related to TCB mode of action consisting of strong increase of intra-tumor T-cells displaying an activated phenotype and increase of CD8/CD4 T-cell ratio (Supplementary Figure 2).