Several factors that are synthesized and released by microglia/TAMs have been reported to increase the invasion of glioblastomas or glioma, such as stress-inducible protein 1 (STI1), epidermal growth factor (EGF), IL-6, and MT1-MMP (membrane type 1-matrix metalloproteinase) (40). This evidence concerns the gene STIP1 and glioma.