Next, our results showed that CYP2J2 disruption by lentivirus-shRNA inhibited tumor growth in vivo (*P < 0.05 vs. U87 + Control shRNA; Figures 5A, B), but did not impact the growth of glioma cells in vitro (not significant vs. Control shRNA; Supplementary Figure 3). The gene discussed is CYP2J2; the disease is central nervous system cancer.