STAT3 and neoplasm: Aggressive tumor features, such as KRAS signaling up (NES = 2.04, FDR q-value = 0.014), EMT (NES = 1.94, FDR q-value = 0.026), myogenesis (NES = 1.82, FDR q-value = 0.033), apical junction (NES = 1.87, FDR q-value = 0.037), angiogenesis (NES = 1.73, FDR q-value = 0.047), IL6/JAK/STAT3 pathway (NES = 1.71, FDR q-value = 0.047), and TGFβ signaling (NES = 2.02, FDR q-value = 0.012) were the most significantly enriched hallmarks under hypoxia (Figure 4A).