Our results indicate that inhibition of FOXQ1 expression decreased the expression of important angiogenic factors in lysates from HUVECs that were cultured in CM from DLD1-shFOXQ1 (left panel of (Figure 5C), as well as in CM from CRC cells (left panel of Figure 5D), these decreased angiogenic factors include ANGPTL4, bFGF, Leptin, CCL2, CXCL16, Follistatin, and VEGF, most of which belong to EGF/PDGF pathway (34). The gene discussed is LEP; the disease is colorectal carcinoma.