In this study, we aimed to synthesize relevant studies that assessed the prognostic value of AR-V7 status for the treatment response of mCRPC patients treated with androgen receptor signalling inhibitors (ARSis) and chemotherapy.<h4>Methods</h4>We searched the PubMed, Embase, and MEDLINE databases by using the keywords <i>AR-V7</i> and <i>prostate cancer</i> to identify relevant studies published before 25 September 2019. Here, AR is linked to Familial prostate cancer.