The functions of angiogenic factors and angiogenesis inhibitors are listed in Table 3. A negative correlation was found between several genes (PSMB8, PSMB9, PSMB10, PSME2, TAP1, IRF1, FBOX6, ETV7) and angiogenic factors (Figure 7A); positive correlations were found for angiogenic inhibitors (Figure 7B), suggesting that these genes might modulate vascular changes in the tumor microenvironment. This evidence concerns the gene PSME2 and neoplasm.