TP53 and cancer: On the other hand, p73 regulates transcription of crucial miRNA genes having several attractive features in the context of cancer therapy including TNBC: 1) p73, unlike p53, is less often mutated in neoplastic disease; 2) its isoform, Tap73, inhibits all cancer features, developing responsiveness to standard radio- and chemotherapies; and 3) p73 replaces p53 functions, inducing the same axes and regulating stress-response pathways and retaining their function when p53 is dysfunctional (69, 118).