Idikio et al. studied the effect of normal aging and events of post-MI remodeling, including the cardio-mechanical and neuro-hormonal factors like immunosenescence, regeneration of stem-cells, telomere shortening, oxidative stress, antiaging hormones like melatonin and klotho, diet, sirtuins and concluded that advances in stem cell repair of myocardial infarcts need further research [2]. This evidence concerns the gene KL and myocardial infarction.