The melanoma cells oscillate between two interchangeable phenotypes using microphthalmia-associated transcription factor (MITF)-rheostat signaling, namely, the proliferative state with high levels of MITF expression (MITFhi) or invasive phenotype with low levels of MITF (MITFlow) (Hoek et al., 2006; Zipser et al., 2011; Kemper et al., 2014). Here, MITF is linked to melanoma.