According to two independent studies reported by researchers from University of Birmingham (Dunwell et al., 2010) and Memorial Sloan-Kettering Cancer Center (Shen et al., 2012), respectively, the methylation of BARHL2 is not only related to hematological and epithelial cancers, but nerve system malignancies including glioma and may play a specific role for the integrative subgrouping of glioma (Shen et al., 2012). The gene discussed is BARHL2; the disease is central nervous system cancer.