It is conceivable that LOC10084876 might interact with REEP1, 2, or 5. Mutations in REEP1 are causative for human autosomal dominant spastic paraplegia 31 (Schlang et al., 2008; Richard et al., 2017) and mutations in REEP2 are causative for spastic paraplegia 72 in humans (Esteves et al., 2014). The gene discussed is REEP1; the disease is Autosomal dominant spastic paraplegia type 31.