SKP1 and neoplasm: We then quantified the expression of DNER, RBPJ, SKP1, CTNNB1, and CDH2 in solid tumor and paratumor paraffin sections by immunohistochemistry and found strong cytoplasmic positivity of DNER in tumor tissue compared with paratumor tissue (Figure 2A), with significant differences (Figure 2C, P < 0.05).