Collectively, the lncRNA-mRNA coexpression network and the – PPI network indicated that the levels of the mRNAs encoding RBPJ, SKP1, CTNNB1, CDH2, SCG2, VGF, and TFF3, which are related to NOTCH and Wnt signaling, were significantly increased in PanNEN tumor tissues compared with the matched paracancer tissues and that these molecules may be involved in the DNER signaling pathway in PanNENs. This evidence concerns the gene CTNNB1 and neoplasm.