For instance, FAM66D is likely specially associated with ALS in brain cortex and RP11-529H20.6 is possibly specifically associated with ALS in brain nucleus accumbens basal ganglia; ATXN3, SCFD1 and SLC9A8 are relevant to ALS in some brain tissues but not others; while C9orf72 is associated with ALS across nearly all brain tissues. The gene discussed is ATXN3; the disease is amyotrophic lateral sclerosis.