SLC9A8 and multiple sclerosis: In the population level, SLC9A8 exhibits widely pleiotropic influence on chronic inflammatory diseases including ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, and ulcerative colitis (Stuart et al., 2010; Ellinghaus et al., 2016); in addition, SLC9A8 is also associated with psoriasis (Stuart et al., 2010), gut microbiota (beta diversity) (Wang et al., 2016) and multiple sclerosis (International Multiple Sclerosis Genetics Consortium, 2013).