While we have not been able to experimentally validate the QuantSeq genes, some of them, including three of the five most differentially expressed ones in KO (Mcur1, FTSJ1, and GPR17) have been linked to neurodegeneration (Liao et al., 2017; Angelova et al., 2020; Bonfanti et al., 2020), or in the case of GPR17, directly linked to ALS. Here, FTSJ1 is linked to amyotrophic lateral sclerosis.