The key genes IGF2, SCD, GALNT1, TLCD1, SHISA9, NLGN1, F13A1, ADAMTS8, GIF, PLD5, SLC13A3, ORM1, BTNL9, PGA5, and PGA4 and RPL5, FGA, and EBF4 were related to clinicopathological parameters and prognoses, which may be used as novel m6A methylation-based molecular markers that can provide accurate targets for the diagnosis and treatment of GC. This evidence concerns the gene RPL5 and gastric cancer.