One of the identified TF–methylation–lncRNA relationships (ELF1-cg05372727- LINC00460) was significantly associated with survival in the training set (log rank p < 0.05, Figures 6A,B) and could also be validated in the testing set (log rank p < 0.05, Figures 6C,D and Supplementary Table 3), which is the potential prognostic biomarker for colon cancer. The gene discussed is ELF1; the disease is malignant colon neoplasm.