Consistently, distinct epigenetic states corresponded to distinct dysfunctional states of tumor-specific CD8+ T cells in tumor mouse model: the “early dysfunctional” TILs obtained a plastic chromatin state that is reprogrammable, whereas the “late dysfunctional” TILs obtained a fixed chromatin state resistant to reprogramming (Schietinger et al., 2016; Philip et al., 2017). This evidence concerns the gene CD8A and neoplasm.