TCF1+ TILs and CXCR5+ TILs have also been observed in human cancer TME; however, whether the human TCF1+ or CXCR5+ TILs resemble their mouse counterparts remains highly controversial (Brummelman et al., 2018; Sade-Feldman et al., 2018). This evidence concerns the gene CXCR5 and cancer.