For example, scRNA-seq on the TME of colorectal tumors identified that intratumoral CXCL13+ TH1-like cells were enriched in microsatellite-instable (MSI) colorectal tumors, which is associated with significantly higher responsiveness to ICB treatment compared to the microsatellite-stable (MSS) colorectal cancers (Zhang et al., 2018). Here, CXCL13 is linked to colorectal neoplasm.