For instance, germ-line deletions of lncRNA ANRIL, located in the CDKN2A/B or INK4-ARF locus on chromosome arm 9p21, have been associated with an increased risk of melanoma and neural system tumor development in several families in the United States and Europe (Bahuau et al., 1998; Pasmant et al., 2007). This evidence concerns the gene CDKN2B-AS1 and melanoma.