Whereas cancer-associated polymorphisms have been recurrently identified within the MALAT1 gene locus (Fujimoto et al., 2016; Rheinbay et al., 2020), recent studies cast doubt on the ability of MALAT1 polymorphism data, alone, to establish a causative relationship between the lncRNA and human disease (Carlevaro-Fita et al., 2020; Rheinbay et al., 2020). Here, MALAT1 is linked to cancer.