SOAT1 and Zika virus infectious disease: Notably, activation of JAK/STAT signaling specifically in the fat body of Ae. aegypti restrains DENV efficiently but fails to restrict ZIKV infection, and priming of these mosquitoes with inactive DENV induces the activation of Notch signaling upon infection with active DENV and reduces viral propagation in the midgut and carcass (20, 21).