ANKLE2 and microcephaly: Expression of the ZIKV non-structural protein NS4A in the brain of Drosophila larvae induces apoptosis and leads to microcephaly, while expression of human Ankyrin Repeat And LEM Domain Containing 2 (ANKLE2) gene, which is involved in brain development and has been previously implicated in hereditary microcephaly, in flies overexpressing ZIKV NS4A abolishes these defects.