-PDT of melanoma cells increased IFNα/β and apoptosis-PDT increased cGAS receptor (not MDA-5, TLR3, RIG-1), p-STAT1 & ISGs (CXCL10, ISG15, MX1)-WT DCs migrated toward PDT melanoma cells more than IFNAR−/− DCs. The gene discussed is ISG15; the disease is melanoma.