A recent phase III trial in SLE did not meet its primary endpoint of response, as per the SLE Responder Index; however, the same group conducted another phase III trial using the of British Isles Lupus Assessment Group (BILAG)-BICLA response as the primary endpoint and reported a statistically significant higher percentage of patients having a response as well as seeing a decrease in secondary endpoints, suggesting that a chronic IFNα response in SLE patients may contribute to disease pathogenesis (48). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.