In vitro: breast—MCF-7, Hs578T, SK-BR-3, HCC70, T47D, melanoma - MDA-MB-435, Squamous - SCC61, Nu61, MES glioma cellsIn vivo: MCF-7 pre-treated anti-APO-1 or IFNβ injected into fat pad NGS mice. This evidence concerns the gene FAS and central nervous system cancer.