-SLFN5 expression increased at basal levels & further induced by IFNα or IFNβ in PDX glioma stem cell & established GBM & MBM cells-SLFN5 co-IP'd with STAT1, not STAT3 or 5, in 293T cells & signal increased with IFNβ treatment. This evidence concerns the gene IFNB1 and central nervous system cancer.