-Long term CD95 stimulation induced type I IFNs, p-STAT1, & increased ISGs in cancer cells-CD95L or type I IFN increased stemness and sphere formation in MCF-7 & SCC61, blocked by JAK1/JAK2i-p-STAT1 correlates with cancer stemness & KO of STAT1 blocked CD95L or type I IFN induced stemness. Here, FASLG is linked to cancer.