Elevated levels of B-cell activating factor (BAFF), a cytokine that promotes the maturation and survival of B-cells, within the serum and lungs of patients with CVID-related ILD levels drives B-cell hyperplasia and may account for disease progression in a small proportion of patients (15) with invasive B cells in inappropriate germinal centers (28, 44). This evidence concerns the gene TNFSF13B and common variable immunodeficiency.