BCAT1 inhibition could provide a therapeutic strategy for MPN patients who have elevated BCAT1 (e.g., patients with EZH2, and possibly ASXL1 and SRSF2 mutations) to shift malignant myeloproliferative hematopoiesis back to normal hematopoiesis. This evidence concerns the gene ASXL1 and myeloproliferative disorder.