Importantly, the Q622L polymorphism in HOIP, which enhances the LUBAC activity, is associated with activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) (44), and c-IAP-1/2–mediated K63-ubiquitination is involved in the LUBAC recruitment and the linear ubiquitination of BCL10 in ABC-DLBCL cells (45). Here, BCL10 is linked to diffuse large B-cell lymphoma.