ITGAM and infection: The number of CD11b+/hiCD11c−/low monocytes plus CD11bhiCD11clow Mc/DC subset in the lungs of klotho KO mice increased at 1 day post-infection and subsequently decreased to the pre-infection level by 7 days post-infection, whereas that of klotho WT mice gradually increased until 3 days post-infection and was decreased at 7 days post-infection (Figure 2E).