Gradual increases were observed for multiple cellular infiltrate measures, such as T-cells (CD3+, CD8+) and dendritic cells (CD11c+), including dendritic cell infiltrates that are characteristic to AD, such as markers typifying “atopic” dendritic cells (OX40L+, FCεR1+) (33, 47, 48) (P<0.05 for CD3+, FCεR1+, OX40L+ in lesional versus normal skin comparisons; Figures 3A–T). The gene discussed is TNFSF4; the disease is Alzheimer disease.